Calorie restriction leads to greater Akt 2 activity and glucose uptake by insulin - stimulated 1 skeletal muscle from old rats 2 3

Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated 1 skeletal muscle from old rats 2 3 Haiyan Wang, Edward B. Arias, and Gregory D. Cartee 4 Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI 5 College of Physical Education and Health, East China Normal University, Shanghai, China 6 Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 7 Institute of Gerontology, University of Michigan, Ann Arbor, MI 8 9 Running title: Calorie restriction and muscle Akt2 in old rats 10 11 Correspondence: 12 Gregory D. Cartee, Ph.D. 13 University of Michigan, School of Kinesiology, Room 4745F 14 401 Washtenaw Avenue, Ann Arbor, MI 48109-2214 15 Phone: (734) 615-3458 16 Fax: (734) 936-1925 17 email: [email protected] 18 Email Addresses: Haiyan Wang, [email protected]; Edward B. Arias, [email protected] 19 20 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (January 6, 2016). doi:10.1152/ajpregu.00449.2015